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Molecular Biosciences Theses and Dissertations

Theses/dissertations from 2024 2024.

Black Holes in TIME: the Effect of GRID Radiation on the Tumor Immune Microenvironment , Rebecca A. Bekker

The Role of L-fucose in Dendritic Cell Antigen Presentation and Polarization , Chase J. Burton

Cornus officinalis extract activates the Keap1/Nrf2 pathway and delays T1D onset in the NOD mouse , Justin D. Fletcher

Androgen Drives Melanoma Invasiveness and Metastatic Spread by Inducing Tumorigenic Fucosylation , Qian Liu

TetR Family Regulator, FarR, Influences Rot-mediated Control of Virulence Factor Expression in Staphylococcus aureus , Julia C. Schumacher

Theses/Dissertations from 2023 2023

Exploring strain variation and bacteriophage predation in the gut microbiome of Ciona robusta , Celine Grace F. Atkinson

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression , Janine M. DeBlasi

Thermodynamic frustration of TAD2 and PRR contribute to autoinhibition of p53 , Emily Gregory

Utilization of Detonation Nanodiamonds: Nanocarrier for Gene Therapy in Non-Small Cell Lung Cancer , Allan E. Gutierrez

Utilizing neoantigen-specific CD4* T cells and immune checkpoint modulation to advance adoptive cell therapy with tumor-infiltrating lymphocytes for metastatic melanoma patients , Maclean Scott Hall

Role of HLA-DRB1 Fucosylation in Anti-Melanoma Immunity , Daniel K. Lester

Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML , Christopher T. Letson

The Role of the DNA Helicase Rrm3 under Replication Stress , Julius Muellner

Regulated Intramembrane Proteolysis by M82 Peptidases: The Role of PrsS in the Staphylococcus aureus Stress Response , Baylie M. Schott

Histone Deacetylase 8 is a Novel Therapeutic Target for Mantle Cell Lymphoma and Preserves Natural Killer Cell Cytotoxic Function , January M. Watters

Theses/Dissertations from 2022 2022

Ceramide-1-Phosphate: A Novel Regulator of Golgi Fragmentation, Golgi-ER Vesicle Trafficking, and Anaplasma phagocytophilum Pathogenesis , Anika Nayar Ali

Regulation of the Heat Shock Response via Lysine Acetyltransferase CBP-1 and in Neurodegenerative Disease in Caenorhabditis elegans , Lindsey N. Barrett

Establishment of a Melanoma ESC-GEMM Platform and Its Use to Study PTEN Tumor Suppressor Functions , Ilah Bok

Adrenergic Modulation of Precursor Cells of Ovarian Cancer , Sweta Dash

Determining the Role of Dendritic Cells During Response to Treatment with Paclitaxel/Anti-TIM-3 , Alycia Gardner

To be or not to be: A Tale of Staphylococcal GpsB , Lauren R. Hammond

Origin and Epigenetic Regulation of Cutaneous T Cell Lymphoma , Carly M. Harro

Cell-free DNA Methylation Signatures in Cancer Detection and Classification , Jinyong Huang

The Role Of Eicosanoid Metabolism in Mammalian Wound Healing and Inflammation , Kenneth D. Maus

A Holistic Investigation of Acidosis in Breast Cancer , Bryce Ordway

Characterizing the Impact of Postharvest Temperature Stress on Polyphenol Profiles of Red and White-Fruited Strawberry Cultivars , Alyssa N. Smith

Identification of Secondary Structural Elements Contained Within the Intrinsically Disordered N-Terminal Tail of the Bloom’s Syndrome Helicase. , Vivek Somasundaram

Defining the role of Oxidized Mitochondrial DNA in Myelodysplastic Syndromes , Grace Anne Ward

Lord of the Z-rings: Uncovering the Role of MraZ and FtsL in Bacillus subtilis Cell Division , Maria Louise White

Theses/Dissertations from 2021 2021

Multifaceted Approach to Understanding Acinetobacter baumannii Biofilm Formation and Drug Resistance , Jessie L. Allen

Cellular And Molecular Alterations Associated with Ovarian and Renal Cancer Pathophysiology , Ravneet Kaur Chhabra

Ecology and diversity of boletes of the southeastern United States , Arian Farid

CircREV1 Expression in Triple-Negative Breast Cancer , Meagan P. Horton

Microbial Dark Matter: Culturing the Uncultured in Search of Novel Chemotaxonomy , Sarah J. Kennedy

The Multifaceted Role of CCAR-1 in the Alternative Splicing and Germline Regulation in Caenorhabditis elegans , Doreen Ikhuva Lugano

Unraveling the Role of Novel G5 Peptidase Family Proteins in Virulence and Cell Envelope Biogenesis of Staphylococcus aureus , Stephanie M. Marroquin

Cytoplasmic Polyadenylation Element Binding Protein 2 Alternative Splicing Regulates HIF1α During Chronic Hypoxia , Emily M. Mayo

Transcriptomic and Functional Investigation of Bacterial Biofilm Formation , Brooke R. Nemec

A Functional Characterization of the Omega (ω) subunit of RNA Polymerase in Staphylococcus aureus , Shrushti B. Patil

The Role Of Cpeb2 Alternative Splicing In TNBC Metastasis , Shaun C. Stevens

Screening Next-generation Fluorine-19 Probe and Preparation of Yeast-derived G Proteins for GPCR Conformation and Dynamics Study , Wenjie Zhao

Theses/Dissertations from 2020 2020

Understanding the Role of Cereblon in Hematopoiesis Through Structural and Functional Analyses , Afua Adutwumwa Akuffo

To Mid-cell and Beyond: Characterizing the Roles of GpsB and YpsA in Cell Division Regulation in Gram-positive Bacteria , Robert S. Brzozowski

Spatiotemporal Changes of Microbial Community Assemblages and Functions in the Subsurface , Madison C. Davis

New Mechanisms That Regulate DNA Double-Strand Break-Induced Gene Silencing and Genome Integrity , Dante Francis DeAscanis

Regulation of the Heat Shock Response and HSF-1 Nuclear Stress Bodies in C. elegans , Andrew Deonarine

New Mechanisms that Control FACT Histone Chaperone and Transcription-mediated Genome Stability , Angelo Vincenzo de Vivo Diaz

Targeting the ESKAPE Pathogens by Botanical and Microbial Approaches , Emily Dilandro

Succession in native groundwater microbial communities in response to effluent wastewater , Chelsea M. Dinon

Role of ceramide-1 phosphate in regulation of sphingolipid and eicosanoid metabolism in lung epithelial cells , Brittany A. Dudley

Allosteric Control of Proteins: New Methods and Mechanisms , Nalvi Duro

Microbial Community Structures in Three Bahamian Blue Holes , Meghan J. Gordon

A Novel Intramolecular Interaction in P53 , Fan He

The Impact of Myeloid-Mediated Co-Stimulation and Immunosuppression on the Anti-Tumor Efficacy of Adoptive T cell Therapy , Pasquale Patrick Innamarato

Investigating Mechanisms of Immune Suppression Secondary to an Inflammatory Microenvironment , Wendy Michelle Kandell

Posttranslational Modification and Protein Disorder Regulate Protein-Protein Interactions and DNA Binding Specificity of p53 , Robin Levy

Mechanistic and Translational Studies on Skeletal Malignancies , Jeremy McGuire

Novel Long Non-Coding RNA CDLINC Promotes NSCLC Progression , Christina J. Moss

Genome Maintenance Roles of Polycomb Transcriptional Repressors BMI1 and RNF2 , Anthony Richard Sanchez IV

The Ecology and Conservation of an Urban Karst Subterranean Estuary , Robert J. Scharping

Biological and Proteomic Characterization of Cornus officinalis on Human 1.1B4 Pancreatic β Cells: Exploring Use for T1D Interventional Application , Arielle E. Tawfik

Evaluation of Aging and Genetic Mutation Variants on Tauopathy , Amber M. Tetlow

Theses/Dissertations from 2019 2019

Investigating the Proteinaceous Regulome of the Acinetobacter baumannii , Leila G. Casella

Functional Characterization of the Ovarian Tumor Domain Deubiquitinating Enzyme 6B , Jasmin M. D'Andrea

Integrated Molecular Characterization of Lung Adenocarcinoma with Implications for Immunotherapy , Nicholas T. Gimbrone

The Role of Secreted Proteases in Regulating Disease Progression in Staphylococcus aureus , Brittney D. Gimza

Advanced Proteomic and Epigenetic Characterization of Ethanol-Induced Microglial Activation , Jennifer Guergues Guergues

Understanding immunometabolic and suppressive factors that impact cancer development , Rebecca Swearingen Hesterberg

Biochemical and Proteomic Approaches to Determine the Impact Level of Each Step of the Supply Chain on Tomato Fruit Quality , Robert T. Madden

Enhancing Immunotherapeutic Interventions for Treatment of Chronic Lymphocytic Leukemia , Kamira K. Maharaj

Characterization of the Autophagic-Iron Axis in the Pathophysiology of Endometriosis and Epithelial Ovarian Cancers , Stephanie Rockfield

Understanding the Influence of the Cancer Microenvironment on Metabolism and Metastasis , Shonagh Russell

Modeling of Interaction of Ions with Ether- and Ester-linked Phospholipids , Matthew W. Saunders

Novel Insights into the Multifaceted Roles of BLM in the Maintenance of Genome Stability , Vivek M. Shastri

Conserved glycine residues control transient helicity and disorder in the cold regulated protein, Cor15a , Oluwakemi Sowemimo

A Novel Cytokine Response Modulatory Function of MEK Inhibitors Mediates Therapeutic Efficacy , Mengyu Xie

Novel Strategies on Characterizing Biologically Specific Protein-protein Interaction Networks , Bi Zhao

Theses/Dissertations from 2018 2018

Characterization of the Transcriptional Elongation Factor ELL3 in B cells and Its Role in B-cell Lymphoma Proliferation and Survival , Lou-Ella M.m. Alexander

Identification of Regulatory miRNAs Associated with Ethanol-Induced Microglial Activation Using Integrated Proteomic and Transcriptomic Approaches , Brandi Jo Cook

Molecular Phylogenetics of Floridian Boletes , Arian Farid

MYC Distant Enhancers Underlie Ovarian Cancer Susceptibility at the 8q24.21 Locus , Anxhela Gjyshi Gustafson

Quantitative Proteomics to Support Translational Cancer Research , Melissa Hoffman

A Systems Chemical Biology Approach for Dissecting Differential Molecular Mechanisms of Action of Clinical Kinase Inhibitors in Lung Cancer , Natalia Junqueira Sumi

Investigating the Roles of Fucosylation and Calcium Signaling in Melanoma Invasion , Tyler S. Keeley

Synthesis, Oxidation, and Distribution of Polyphenols in Strawberry Fruit During Cold Storage , Katrina E. Kelly

Investigation of Alcohol-Induced Changes in Hepatic Histone Modifications Using Mass Spectrometry Based Proteomics , Crystina Leah Kriss

Off-Target Based Drug Repurposing Using Systems Pharmacology , Brent M. Kuenzi

Investigation of Anemarrhena asphodeloides and its Constituent Timosaponin-AIII as Novel, Naturally Derived Adjunctive Therapeutics for the Treatment of Advanced Pancreatic Cancer , Catherine B. MarElia

The Role of Phosphohistidine Phosphatase 1 in Ethanol-induced Liver Injury , Daniel Richard Martin

Theses/Dissertations from 2017 2017

Changing the Pathobiological Paradigm in Myelodysplastic Syndromes: The NLRP3 Inflammasome Drives the MDS Phenotype , Ashley Basiorka

Modeling of Dynamic Allostery in Proteins Enabled by Machine Learning , Mohsen Botlani-Esfahani

Uncovering Transcriptional Activators and Targets of HSF-1 in Caenorhabditis elegans , Jessica Brunquell

The Role of Sgs1 and Exo1 in the Maintenance of Genome Stability. , Lillian Campos-Doerfler

Mechanisms of IKBKE Activation in Cancer , Sridevi Challa

Discovering Antibacterial and Anti-Resistance Agents Targeting Multi-Drug Resistant ESKAPE Pathogens , Renee Fleeman

Functional Roles of Matrix Metalloproteinases in Bone Metastatic Prostate Cancer , Jeremy S. Frieling

Disorder Levels of c-Myb Transactivation Domain Regulate its Binding Affinity to the KIX Domain of CREB Binding Protein , Anusha Poosapati

Role of Heat Shock Transcription Factor 1 in Ovarian Cancer Epithelial-Mesenchymal Transition and Drug Sensitivity , Chase David Powell

Cell Division Regulation in Staphylococcus aureus , Catherine M. Spanoudis

A Novel Approach to the Discovery of Natural Products From Actinobacteria , Rahmy Tawfik

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Home > Life Sciences > Microbiology and Molecular Biology > Theses and Dissertations

Microbiology and Molecular Biology Theses and Dissertations

Theses/dissertations from 2024 2024.

Characterization of Cellular Metabolism Regulation by the Transcription Factor Centromere Binding Factor 1 (Cbf1) , Spencer Ellsworth

Connecting HIV-1 Viral Protein R Polymorphisms to Changes in Inflammatory Signals and Efficacy Testing of Essential Oils as Disinfectants Against SARS-CoV-2 , J. Brandon Lopez

The Effects of Combining β-lactam Antibiotics and Mefloquine in Multi-Drug ResistantPseudomonas aeruginosa , Kayla C. Maas

Laying Framework for a Novel In Vitro Eukaryotic System to Measure Rate of Transcription Elongation , John Lucas Ramirez

Theses/Dissertations from 2023 2023

Elucidating the Architecture of the TclIJN Complex that Converts Cysteine to Thiazoles in the Biosynthesis of Micrococcin , Diana G. Calvopina Chavez

Manipulating and Assaying Chromatin Architecture Around Enhancer Elements in vivo , John Lawrence Carter

Using de novo Transcriptomes to Decipher the Relationships in Cutthroat Trout Subspecies (Oncorhynchus clarkii) , Andrea Leena Kokkonen

Characterization of Phage-Host Interactions and its Impact on Tail Fiber Evolution , Jessica Marie Lewis

Halophilic Genes that Impact Plant Growth in Saline Soils , Mckay A. Meinzer

Characterizing Stress Granule Regulation by PAS Kinase, Ataxin-2 and Ptc6 and Investigating the Lifespan of Covid-19 Virus on Currency , Colleen R. Newey

Changes in RNA Expression of HuT78 Cells Resulting From the HIV-1 Viral Protein R R77Q Mutation , Joshua S. Ramsey

Theses/Dissertations from 2022 2022

Biofilm Characterization and the Potential Role of eDNA in Horizontal Gene Transfer in Hospital and Meat Isolates of Staphylococcus aureus and Their Biofilms , Ashley Lynne Ball

Novel Patterns for Nucleosome Positioning: From in vitro to in vivo , David Andrew Bates

The Effects of Polymorphisms of Viral Protein R of HIV-1 on the Induction of Apoptosis in Primary Cells and the Characterization of Twelve Novel Bacillus anthracis Bacteriophage , Jacob D. Fairholm

Analysis of the Cytopathogenic Effect of Different HIV-1 Vpr Isoforms on Primary Human CD4+ T Cells and a Model Cell Line , Jonatan Josue Fierro Nieves

The Role of Chitinase A in Mastitis-Associated Escherichia coli Pathogenesis , Weston D. Hutchison

Big Data Meta-Analyses of Transcriptional Responses of Human Samples to Orthohantavirus Infection and Shotgun Metagenomics From Crohn's Disease Patients. , John L. Krapohl

An Exploration of Factors that Impact Uptake of Human Papillomavirus Vaccines , David Samuel Redd

Genomic Analysis and Therapeutic Development of Bacteriophages to Treat Bacterial Infections and Parasitic Infestations , Daniel W. Thompson

The Use of Nucleotide Salvage Pathway Enzymes as Suitable Tumor Targets for Antibody-Based and Adoptive Cell Therapies , Edwin J. Velazquez

Comparative Sequence Analysis Elucidates the Evolutionary Patterns of Yersinia pestis in New Mexico over Thirty-Two Years , M. Elizabeth Warren

Regulation of T Cell Activation by the CD5 Co-Receptor and Altered Peptides, Characterization of Thymidine Kinase-Specific Antibodies, and Integrating Genomics Education in Society , Kiara Vaden Whitley

Theses/Dissertations from 2021 2021

Evolution and Selection: From Suppression of Metabolic Deficiencies to Bacteriophage Host Range and Resistance , Daniel Kurt Arens

Identifying Sinorhizobium meliloti Genes that Determine Fitness Outcomes , Alexander B. Benedict

Pushing the Limits of SARS-CoV-2 Survival: How SARS-CoV-2 Responds to Quaternary Ammonium Compounds and Wastewater , Benjamin Hawthorne Ogilvie

Mutations in HIV-1 Vpr Affect Pathogenesis in T-Lymphocytes and Novel Strategies to Contain the Current COVID-19 Pandemic , Antonio Solis Leal

Theses/Dissertations from 2020 2020

Staphylococcus aureus Metal Acquisition in Milk and Mammary Gland Tissue , Shalee Killpack Carlson

Antimicrobial Peptide Development: From Massively Parallel Peptide Sequencing to Bioinformatic Motif Identification , Alexander K. Erikson

A Comparison of Chikungunya Virus Infection, Dissemination, and Cytokine Induction in Human and Murine Macrophages and Characterization of RAG2-/-γc-/- Mice as an Animal Model to Study Neurotropic Chikungunya Disease , Israel Guerrero

The Effects of Immune Regulation and Dysregulation: Helper T Cell Receptor Affinity, Systemic Lupus Erythematosus and Cancer Risk, and Vaccine Hesitancy , Deborah K. Johnson

Identification of Genes that Determine Fitness, Virulence, and Disease Outcomes in Mastitis Associated Eschericia coli , Michael Andrew Olson

Theses/Dissertations from 2019 2019

Investigation of Thymidine Kinase 1 in Cancer Progression , Eliza Esther King Bitter

Ribosomally Synthesized and Post-Translationally Modified Peptides as Potential Scaffolds for Peptide Engineering , Devan Bursey

Bioaerosols Associated with Evaporative Cooler Use in Low-Income Homes in Semi-Arid Climates , Ashlin Elaine Cowger

PAS Kinase and TOR, Controllers of Cell Growth and Proliferation , Brooke Jasmyn Cozzens

Regulation of Immune Cell Activation and Functionby the nBMPp2 Protein andthe CD5 Co-Receptor , Claudia Mercedes Freitas

Characterizing Novel Pathways for Regulation and Function of Ataxin-2 , Elise Spencer Melhado

Interactions Between the Organellar Pol1A, Pol1B, and Twinkle DNA Replication Proteins and Their Role in Plant Organelle DNA Replication , Stewart Anthony Morley

SNFing Glucose to PASs Mitochondrial Dysfunction: The Role of Two Sensory Protein Kinases in Metabolic Diseases , Kai Li Ong

Characterizing the Function of PAS kinase in Cellular Metabolism and Neurodegenerative Disease , Jenny Adele Pape

Isolation, Characterization, and Genomic Comparison of Bacteriophages of Enterobacteriales Order , Ruchira Sharma

Isolation, Genetic Characterization and Clinical Application of Bacteriophages of Pathogenic Bacterial Species , Trever Leon Thurgood

Investigation of Therapeutic Immune Cell Metabolism , Josephine Anna Tueller

Theses/Dissertations from 2018 2018

Innate Immune Cell Phenotypes Are Dictated by Distinct Epigenetic Reprogramming , Kevin Douglas Adams

Bacteriophages for Treating American Foulbrood and the Neutralization of Paenibacillus larvae Spores , Thomas Scott Brady

Methods for Detection of and Therapy for Carbapenem-Resistant Enterobacteriaceae , Olivia Tateoka Brown

The Diversity Found Among Carbapenem-Resistant Bacteria , Galen Edward Card

Exploration of Antimicrobial Activity in Natural Peptides and High-Throughput Discovery of Synthetic Peptides , Emma Kay Dallon

Gut Microbiota Regulates the Interplay Between Diet and Genetics to Influence Insulin Resistance , Jeralyn Jones Franson

The Antimicrobial Properties of Honey and Their Effect on Pathogenic Bacteria , Shreena Himanshu Mody

The Ability of Novel Phage to Infect Virulent Bacillus anthracis Isolates , Hyrum Smith Shumway

Galleria Mellonella as an Alternate Infection Model for Burkholderia Species and a Comparison of Suspension and Surface Test Methods for Evaluating Sporicidal Efficacy , Joseph D. Thiriot

The Clinical Significance of HPRT as a Diagnostic and Therapeutic Biomarker for Hematological and Solid Malignancies , Michelle Hannah Townsend

Biomarker Analysis and Clinical Relevance of Thymidine Kinase 1 in Solid and Hematological Malignancies , Evita Giraldez Weagel

Hospital and meat associated Staphylococcus aureus and Their Biofilm Characteristics , Trevor Michael Wienclaw

Theses/Dissertations from 2017 2017

Comparison of Cytokine Expression and Bacterial Growth During Periparturient and Mid Lactation Mastitis in a Mouse Model , Rhonda Nicole Chronis

Influence of Epstein-Barr Virus on Systemic Lupus Erythematosus Disease Development and the Role of Depression on Disease Progression , Caleb Cornaby

The Effects of Nucleosome Positioning and Chromatin Architecture on Transgene Expression , Colton E. Kempton

Phosphate Signaling Through Alternate Conformations of the PstSCAB Phosphate Transporter , Ramesh Krishna Vuppada

Acetobacter fabarum Genes Influencing Drosophila melanogaster Phenotypes , Kylie MaKay White

Theses/Dissertations from 2016 2016

The Path to Understanding Salt Tolerance: Global Profiling of Genes Using Transcriptomics of the Halophyte Suaeda fruticosa , Joann Diray Arce

Genetic and Biochemical Analysis of the Micrococcin Biosynthetic Pathway , Philip Ross Bennallack

Characterizing Interaction Between PASK and PBP1/ ATXN2 to Regulate Cell Growth and Proliferation , Nidhi Rajan Choksi

The Activity of Alkaline Glutaraldehyde Against Bacterial Endospores and Select Non-Enveloped Viruses , Justen Thalmus Despain

The Role of Viral Interleukin-6 in Tumor Development of Kaposi's Sarcoma-Associated Herpesvirus Lymphomas , Rebecca A. Fullwood

The Role of the Transcriptional Antiterminator RfaH in Lipopolysaccharide Synthesis, Resistance to Antimicrobial Peptides, and Virulence of Yersinia pseudotuberculosis and Yersinia pestis , Jared Michael Hoffman

A CryAB Interactome Reveals Clientele Specificity and Dysfunction of Mutants Associated with Human Disease , Whitney Katherine Hoopes

The pmrHFIJKLM Operon in Yersinia pseudotuberculosis Enhances Resistance to CCL28 and Promotes Phagocytic Engulfment by Neutrophils , Lauren Elizabeth Johnson

Characterization of Five Brevibacillus Bacteriophages and Their Genomes , Michael Allen Sheflo

Analysis of Nucleosome Isolation and Recovery: From In Silico Invitrosomes to In Vivo Nucleosomes , Collin Brendan Skousen

Human Herpesvirus 6A Infection and Immunopathogenesis in Humanized Rag2 -/-γc-/- Mice and Relevance to HIV/AIDS and Autoimmunity , Anne Tanner

Theses/Dissertations from 2015 2015

Identifying and Characterizing Yeast PAS Kinase 1 Substrates Reveals Regulation of Mitochondrial and Cell Growth Pathways , Desiree DeMille

The Detection and Molecular Evolution of Francisella tularensis Subspecies , Mark K. Gunnell

Isolation and Host Range of Staphylococcus aureus Bacteriophages and Use for Decontamination of Fomites , Kyle C. Jensen

The Antioxidant and DNA Repair Capacities of Resveratrol, Piceatannol, and Pterostilbene , Justin Ryan Livingston

High Salinity Stabilizes Bacterial Community Composition and Activity Through Time , Tylan Wayne Magnusson

Advancing Phage Genomics and Honeybee Health Through Discovery and Characterization of Paenibacillaceae Bacteriophages , Bryan Douglas Merrill

Specialized Replication Operons Control Rhizobial Plasmid Copy Number in Developing Symbiotic Cells , Clarice Lorraine Perry

Gene Networks Involved in Competitive Root Colonization and Nodulation in the Sinorhizobium meliloti-Medicago truncatula Symbiosis , Ryan D. VanYperen

Theses/Dissertations from 2014 2014

Snf1 Mediated Phosphorylation and Activation of PAS Kinase , Bryan D. Badal

Studies of PhoU in Escherichia coli: Metal Binding, Dimerization,Protein/Protein Interactions, and a Signaling Complex Model , Stewart G. Gardner

Pharmacologic Immunomodulation of Macrophage Activation by Caffeine , Ryan Perry Steck

Analysis of Nucleosome Mobility, Fragility, and Recovery: From Embryonic Stem Cells to Invitrosomes , Ashley Nicolle Wright

Enhancing Protein and Enzyme Stability Through Rationally Engineered Site-Specific Immobilization Utilizing Non-Canonical Amino Acids , Jeffrey Chun Wu

Theses/Dissertations from 2013 2013

Thymidine Kinase 1: Diagnostic and Prognostic Significance in Malignancy , Melissa Marie Alegre

Promoter Polymorphisms in Interferon Regulatory Factor 5 , Daniel N. Clark

Modulators of Symbiotic Outcome in Sinorhizobium meliloti , Matthew B. Crook

Evidences for Protein-Protein Interactions Between PstB and PhoU in the Phosphate Signaling Complex of Escherichia coli , Kristine Dawn Johns

Identification of the Binding Partners for HspB2 and CryAB Reveals Myofibril and Mitochondrial Protein Interactions and Non-Redundant Roles for Small Heat Shock Proteins , Kelsey Murphey Langston

A Quadruplex Real-Time PCR Assay for the Rapid Detection and Differentiation of the Burkholderia pseudomallei Complex: B. mallei , B. pseudomallei , and B. thailandensis , Chinn-woan Lowe

The Role of Nuclear BMP2 in the Cell Cycle and Tumorigenesis , Brandt Alan Nichols

Nuclear BMP2 and the Immune Response , Daniel S. Olsen

Hypersaline Lake Environments Exhibit Reduced Microbial Dormancy , Joshua Christopher Vert

Theses/Dissertations from 2012 2012

Characterization of the Cellular and Organellar Dynamics that Occur with a Partial Depletion of Mitochondrial DNA when Arabidopsis Organellar DNA Polymerase IB is Mutated , John D. Cupp

Effect of Antioxidants and Oxidative Stress on Different Cancer Cell Types , Gaytri Devi Gupta Elera

Effects of Chemical Stimulation and Tumor Co-Incubation on Macrophage Activation and Aggressiveness, Measured Through Phagocytosis and Respiratory Burst , Bo Marcus Gustafsson

Loss of the Lipopolysaccharide Core Biosynthesis rfaD Gene Increases Antimicrobial Chemokine Binding and Bacterial Susceptibility to CCL28 and Polymyxin: A Model for Understanding the Interface of Antimicrobial Chemokines and Bacterial Host Defense Avoidance Mechanisms , Cynthia S. Lew

Partial Characterization of the Antimicrobial Activity of CCL28 , Bin Liu

Characterizing the Role of HspB2 in Cardiac Metabolism and Muscle Structure Using Yeast and Mammalian Systems , Jonathan Paul Neubert

Humanized Mice as a Model to Study Human Viral Pathogenesis and Novel Antiviral Drugs , Freddy Mauricio Sanchez Tumbaco

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Molecular and Cellular Biology Masters Theses

Permanent uri for this collection, recent submissions.

Science Thesis Topics

300 Science Thesis Topics and Ideas

Science is a vast and ever-evolving field that encompasses numerous disciplines and research areas. From the complexities of molecular biology to the abstract theories of applied mathematics, science provides a broad range of opportunities for inquiry. A strong thesis topic is essential for contributing to the advancement of scientific knowledge, addressing current challenges, and shaping future innovations. This list of 300 science thesis topics, divided into 10 categories, covers key scientific disciplines and reflects current issues, emerging trends, and future directions in science.

Academic Writing, Editing, Proofreading, And Problem Solving Services

Get 10% off with 24start discount code, 1. applied mathematics thesis topics.

• The role of stochastic processes in financial modeling.
• Mathematical optimization techniques for energy-efficient transportation systems.
• Application of game theory in decision-making processes.
• The use of machine learning algorithms in solving complex differential equations.
• Exploring fractals in nature: Mathematical models and applications.
• Topological methods for data analysis in high-dimensional spaces.
• Mathematical modeling of infectious disease outbreaks.
• The role of computational geometry in computer vision.
• Optimization algorithms in machine learning.
• The impact of nonlinear dynamics on weather forecasting models.
• Mathematical models for understanding traffic flow dynamics.
• The use of graph theory in social network analysis.
• Chaos theory applications in environmental systems.
• Mathematical models of quantum computing processes.
• The role of partial differential equations in describing fluid dynamics.
• Investigating mathematical approaches to cryptography and secure communications.
• Mathematical modeling of population dynamics in ecology.
• Applications of number theory in cryptographic systems.
• Mathematical theories behind artificial neural networks.
• The application of Markov chains in queueing theory.
• Understanding the mathematics behind black hole thermodynamics.
• The role of calculus in understanding electromagnetic fields.
• Mathematical approaches to solving real-world logistics and supply chain problems.
• Statistical models for risk assessment in finance and insurance.
• Exploring differential geometry in the context of general relativity.
• The application of game theory to environmental economics.
• Investigating Monte Carlo methods for stochastic simulations.
• Using graph theory for optimal network design in telecommunications.
• Mathematical approaches to optimization problems in artificial intelligence.
• Analyzing the role of Fourier transforms in signal processing.

2. Biology Thesis Topics

• The role of CRISPR technology in gene editing and its ethical implications.
• Investigating the effects of climate change on biodiversity in tropical ecosystems.
• The impact of microplastics on marine organisms and ecosystems.
• Genetic factors contributing to cancer resistance in certain species.
• The role of the microbiome in human health and disease.
• Investigating stem cell therapy for the treatment of neurodegenerative diseases.
• Exploring the genetic basis of antibiotic resistance in bacteria.
• The impact of habitat fragmentation on species survival and reproduction.
• The role of epigenetics in developmental biology.
• Investigating the molecular mechanisms of aging in mammals.
• The role of photosynthesis in global carbon cycles and climate regulation.
• The effects of invasive species on native biodiversity and ecosystem functions.
• Exploring the molecular pathways involved in immune system regulation.
• The role of RNA interference in regulating gene expression.
• Investigating the evolutionary mechanisms driving speciation in isolated populations.
• The impact of pollution on reproductive health in amphibians.
• Investigating the genetic basis of human diseases using model organisms.
• The role of protein folding in neurodegenerative diseases like Alzheimer’s.
• Exploring plant adaptations to extreme environments such as deserts.
• Investigating the relationship between genetics and behavior in animal populations.
• The role of biodiversity in maintaining ecosystem services.
• Investigating the molecular mechanisms of disease resistance in plants.
• The impact of deforestation on animal migration patterns.
• Investigating the role of hormones in animal reproductive behaviors.
• The impact of climate change on migration patterns of birds and insects.
• The role of biotechnology in developing sustainable agricultural practices.
• Investigating the role of bioinformatics in identifying disease biomarkers.
• The effects of nanotechnology on biological systems and health.
• Exploring gene therapy approaches for treating inherited genetic disorders.
• The role of bioluminescence in marine ecosystems and its potential applications.

3. Botany Thesis Topics

• Investigating the effects of climate change on plant phenology.
• The role of plant hormones in regulating growth and development.
• Exploring plant responses to drought stress at the molecular level.
• Investigating the role of mycorrhizal fungi in plant nutrient uptake.
• The impact of invasive plant species on native ecosystems.
• Exploring the potential of genetically modified crops for sustainable agriculture.
• The role of plant secondary metabolites in defense against herbivores.
• Investigating plant-pollinator interactions in fragmented habitats.
• The effects of soil composition on plant growth and health.
• The role of photosynthesis in plant adaptation to changing environments.
• Investigating the impact of air pollution on plant physiology.
• Exploring plant symbiosis with nitrogen-fixing bacteria in agriculture.
• Investigating the role of polyploidy in plant evolution.
• The effects of light intensity on plant growth and development.
• The role of genetic diversity in the survival of plant populations.
• Investigating the potential of medicinal plants in drug discovery.
• Exploring plant adaptation strategies in arid environments.
• The role of epigenetic modifications in plant stress responses.
• Investigating the role of endophytes in plant health and disease resistance.
• The effects of heavy metal contamination on plant growth and soil health.
• Exploring the genetic basis of seed dormancy in wild and cultivated plants.
• The role of allelopathy in plant competition and ecosystem dynamics.
• Investigating the impact of climate change on alpine plant species.
• Exploring plant-based solutions for soil erosion control.
• Investigating the role of hormones in plant defense mechanisms.
• The potential of vertical farming for sustainable food production.
• Exploring plant responses to salinity stress in coastal ecosystems.
• The role of transgenic plants in bioremediation of polluted environments.
• Investigating plant biodiversity in tropical rainforests and its conservation.
• The effects of herbicides on non-target plant species and ecosystems.

4. Chemistry Thesis Topics

• Investigating the role of catalysts in green chemistry.
• The impact of nanomaterials on drug delivery systems.
• Exploring the chemistry behind renewable energy storage solutions.
• The role of chemical sensors in detecting environmental pollutants.
• Investigating the chemistry of bioplastics and their environmental impact.
• Exploring chemical reactions in atmospheric chemistry and climate change.
• The role of chemical compounds in developing antiviral drugs.
• Investigating the molecular structure of proteins using X-ray crystallography.
• Exploring the use of green solvents in organic synthesis.
• The role of photochemistry in developing solar energy technologies.
• Investigating the role of transition metals in catalysis.
• Exploring chemical methods for water purification and desalination.
• The impact of chemical pollutants on human health and ecosystems.
• Investigating the properties of supercapacitors for energy storage.
• The role of organic chemistry in drug design and development.
• Exploring the chemistry of rare earth elements in electronic devices.
• Investigating the chemistry of lithium-ion batteries for electric vehicles.
• The role of molecular simulations in understanding chemical reactions.
• Investigating the chemical basis of enzyme catalysis in biological systems.
• Exploring chemical approaches to carbon capture and storage technologies.
• Investigating the role of polymers in biomedical applications.
• The impact of chemical fertilizers on soil health and plant growth.
• Exploring the use of quantum chemistry in understanding molecular behavior.
• Investigating the role of chemical sensors in monitoring air quality.
• The role of synthetic organic chemistry in the development of pharmaceuticals.
• Investigating the chemistry of antioxidants and their effects on human health.
• Exploring the impact of industrial chemical processes on global warming.
• The role of computational chemistry in drug discovery.
• Investigating chemical pathways for converting biomass into biofuels.
• Exploring the chemistry of corrosion and its prevention in engineering materials.

5. Environmental Science Thesis Topics

• Investigating the impact of climate change on coastal ecosystems.
• The role of renewable energy in reducing global carbon emissions.
• The effects of deforestation on biodiversity in tropical rainforests.
• Exploring sustainable agricultural practices to combat soil degradation.
• The role of environmental policies in mitigating air pollution in urban areas.
• Investigating the effects of plastic pollution on marine ecosystems.
• The role of environmental education in promoting sustainable behavior.
• Exploring the impact of urbanization on freshwater resources.
• The role of wetlands in carbon sequestration and climate regulation.
• Investigating the potential of biofuels as a sustainable energy source.
• The effects of mining activities on groundwater contamination.
• Exploring the role of green infrastructure in urban flood management.
• Investigating the impact of agricultural pesticides on pollinator populations.
• The role of international environmental agreements in addressing climate change.
• The effects of ocean acidification on coral reefs and marine biodiversity.
• Exploring the impact of ecotourism on conservation efforts in protected areas.
• Investigating the role of forests in regulating global water cycles.
• The impact of climate-induced migration on political stability in developing countries.
• Exploring the role of public policy in promoting renewable energy adoption.
• The effects of microplastics on the food chain and human health.
• Investigating the potential of circular economy models in reducing waste.
• The role of reforestation in combating desertification in arid regions.
• The impact of extreme weather events on agricultural productivity.
• Exploring the role of environmental NGOs in global conservation efforts.
• Investigating the effects of urban sprawl on wildlife habitats.
• The role of environmental justice in addressing the disproportionate impact of pollution on marginalized communities.
• Exploring the potential of carbon offset markets in reducing global emissions.
• Investigating the role of environmental law in protecting endangered species.
• The impact of climate change on global food security.
• Exploring the role of ecosystem services in promoting sustainable development.

6. Geography Thesis Topics

• Investigating the role of geographical information systems (GIS) in disaster management.
• The impact of urbanization on landscape changes and environmental degradation.
• Exploring the effects of climate change on glacier retreat and water resources.
• The role of geographic factors in the spread of infectious diseases.
• Investigating the socio-economic impacts of gentrification in urban areas.
• Exploring the relationship between deforestation and rural poverty in developing countries.
• The role of geography in shaping patterns of human migration and resettlement.
• Investigating the impact of coastal erosion on communities and infrastructure.
• The role of remote sensing in monitoring environmental change.
• Exploring the spatial distribution of renewable energy resources across the globe.
• Investigating the geographic factors influencing access to healthcare in rural areas.
• The impact of climate change on agriculture and food production in different regions.
• Exploring the role of geography in international trade and global supply chains.
• Investigating the effects of urban planning on transportation networks in major cities.
• The role of GIS in assessing the risk of natural disasters such as floods and earthquakes.
• Exploring the geographic distribution of endangered species and conservation efforts.
• Investigating the influence of geography on political boundaries and border disputes.
• The impact of tourism on the environment and local economies in coastal regions.
• Exploring the role of climate change in shaping migration patterns in developing countries.
• Investigating the effects of population growth on land use and environmental sustainability.
• The role of geography in shaping cultural identity and regional development.
• Exploring the geographic factors influencing energy consumption patterns.
• Investigating the spatial distribution of poverty and wealth in urban areas.
• The impact of global warming on sea level rise and coastal vulnerability.
• Exploring the role of geographic factors in conflict and political instability.
• Investigating the impact of natural disasters on population displacement and migration.
• The role of geography in shaping patterns of inequality in education and healthcare.
• Exploring the geographic implications of resource extraction in developing countries.
• Investigating the effects of globalization on rural and urban landscapes.
• The role of GIS in urban planning and sustainable development.

7. Geology Thesis Topics

• Investigating the formation of volcanic islands and their geological features.
• The role of plate tectonics in shaping the Earth’s landscape and geological formations.
• Exploring the effects of soil erosion on agricultural productivity and land degradation.
• The impact of mining activities on geological structures and ecosystems.
• Investigating the role of groundwater in shaping karst landscapes.
• The effects of climate change on permafrost and its implications for infrastructure.
• Exploring the geological history of mass extinction events and their causes.
• Investigating the role of sedimentation in coastal and river delta formations.
• The impact of earthquakes on geological faults and seismic activity.
• Exploring the role of glaciers in shaping mountain landscapes.
• Investigating the formation and distribution of fossil fuels in sedimentary basins.
• The role of geologic processes in the formation of mineral deposits.
• Exploring the impact of human activities on the stability of geological formations.
• Investigating the role of volcanic activity in shaping oceanic islands.
• The effects of deforestation on soil stability and erosion in mountainous regions.
• Exploring the role of geologic processes in the formation of natural gas reserves.
• Investigating the impact of volcanic eruptions on climate and atmospheric conditions.
• The role of geology in understanding and predicting natural hazards such as landslides.
• Exploring the geological history of the Earth’s climate and its impact on life.
• Investigating the role of subduction zones in the formation of mountain ranges.
• The impact of sea-level rise on coastal geology and sedimentation patterns.
• Exploring the formation of caves and underground water systems in karst regions.
• Investigating the effects of glaciation on soil composition and landscape features.
• The role of geology in assessing the risks of earthquakes and tsunamis in coastal areas.
• Exploring the formation of metamorphic rocks and their role in the Earth’s crust.
• Investigating the impact of mining on groundwater contamination and geological stability.
• The role of geology in understanding the Earth’s magnetic field and its changes over time.
• Exploring the formation of deserts and the geological processes that shape them.
• Investigating the role of geological surveys in the exploration of natural resources.
• The impact of geological changes on ecosystems and biodiversity over geological time.

8. Molecular Biology Thesis Topics

• Investigating the molecular mechanisms of DNA repair in response to UV radiation.
• The role of transcription factors in gene expression and regulation.
• Exploring the molecular basis of cancer cell resistance to chemotherapy.
• Investigating the role of microRNAs in regulating cellular differentiation.
• The molecular mechanisms of protein folding and misfolding in neurodegenerative diseases.
• Exploring the molecular pathways involved in cell cycle regulation and cancer.
• Investigating the role of epigenetic modifications in gene expression and inheritance.
• The molecular basis of antibiotic resistance in pathogenic bacteria.
• Exploring the molecular mechanisms of immune system activation and response.
• Investigating the role of molecular chaperones in protein folding and stability.
• The molecular pathways involved in apoptosis and programmed cell death.
• Exploring the molecular mechanisms of viral replication and host cell invasion.
• Investigating the role of molecular signaling pathways in stem cell differentiation.
• The molecular basis of genetic mutations and their role in hereditary diseases.
• Exploring the molecular mechanisms of plant immune responses to pathogens.
• Investigating the role of molecular interactions in enzyme catalysis and regulation.
• The molecular basis of gene editing technologies such as CRISPR-Cas9.
• Exploring the molecular pathways involved in aging and cellular senescence.
• Investigating the role of molecular motors in intracellular transport and cell division.
• The molecular basis of signal transduction pathways in cancer cells.
• Exploring the molecular mechanisms of hormone signaling in plants and animals.
• Investigating the molecular basis of synaptic plasticity and memory formation.
• The role of molecular biology in developing targeted therapies for genetic disorders.
• Exploring the molecular mechanisms of viral evasion of the immune system.
• Investigating the role of molecular clocks in understanding evolutionary processes.
• The molecular basis of immune tolerance and autoimmunity.
• Exploring the role of molecular biology in understanding the genetics of rare diseases.
• Investigating the molecular basis of drug resistance in cancer cells.
• The role of molecular biology in understanding the regulation of metabolic pathways.
• Exploring the molecular mechanisms of gene-environment interactions in human diseases.

9. Physics Thesis Topics

• Investigating the role of quantum mechanics in understanding black hole thermodynamics.
• The impact of dark matter on the formation of galaxies and cosmic structures.
• Exploring the physics behind superconductivity and its potential applications.
• Investigating the role of particle physics in understanding the fundamental forces of nature.
• The physics of climate change: Understanding the role of energy transfer in global warming.
• Exploring the principles of quantum computing and its applications in cryptography.
• Investigating the physics behind nuclear fusion as a potential energy source.
• The role of gravitational waves in understanding the structure of the universe.
• Exploring the physics of turbulence in fluids and its applications in engineering.
• Investigating the role of quantum entanglement in the development of quantum networks.
• The physics of renewable energy: Understanding the principles behind solar and wind energy.
• Exploring the role of general relativity in predicting the behavior of black holes.
• Investigating the physics of particle accelerators and their role in high-energy physics.
• The impact of quantum mechanics on understanding the behavior of atomic and subatomic particles.
• Exploring the principles of thermodynamics in understanding energy transfer and efficiency.
• Investigating the role of string theory in unifying the fundamental forces of nature.
• The physics of light and its applications in developing new technologies.
• Exploring the principles of quantum field theory in understanding the behavior of particles.
• Investigating the role of statistical mechanics in understanding the behavior of gases and liquids.
• The physics of space exploration: Understanding the principles behind rocket propulsion.
• Exploring the role of electromagnetism in developing new communication technologies.
• Investigating the physics behind the formation of stars and planetary systems.
• The impact of quantum mechanics on understanding the behavior of materials at the nanoscale.
• Exploring the principles of fluid dynamics in understanding the behavior of liquids and gases.
• Investigating the role of quantum mechanics in developing new technologies such as quantum sensors.
• The physics of time travel: Exploring the theoretical possibilities and challenges.
• Exploring the role of nuclear physics in understanding the behavior of atomic nuclei.
• Investigating the physics of solid-state materials and their applications in electronics.
• The role of quantum mechanics in understanding the behavior of complex systems.
• Exploring the principles of chaos theory in understanding the behavior of dynamic systems.

10. Zoology Thesis Topics

• Investigating the impact of climate change on animal migration patterns.
• The role of animal behavior in shaping predator-prey relationships.
• Exploring the effects of habitat loss on the biodiversity of endangered species.
• Investigating the role of genetics in animal adaptation to environmental changes.
• The impact of invasive species on native animal populations and ecosystems.
• Exploring the role of animal communication in social behaviors and survival strategies.
• Investigating the effects of pollution on reproductive health in marine animals.
• The role of animal cognition in problem-solving and decision-making.
• Exploring the impact of urbanization on wildlife behavior and habitat use.
• Investigating the role of genetics in the evolution of animal species.
• The effects of climate change on animal breeding patterns and reproductive success.
• Exploring the role of conservation biology in protecting endangered species.
• Investigating the impact of human activities on the behavior and survival of marine mammals.
• The role of animal physiology in adapting to extreme environmental conditions.
• Exploring the relationship between animal nutrition and growth in different species.
• Investigating the role of social structures in shaping animal behavior in primates.
• The impact of deforestation on animal populations and their habitats.
• Exploring the role of animal behavior in shaping mating strategies and reproductive success.
• Investigating the effects of climate change on animal disease transmission and outbreaks.
• The role of animal behavior in shaping group dynamics and social hierarchies.
• Exploring the impact of habitat fragmentation on animal movement and dispersal.
• Investigating the role of genetics in animal domestication and breeding.
• The effects of human activities on animal migration routes and patterns.
• Exploring the role of animal behavior in predator-prey interactions in marine ecosystems.
• Investigating the impact of climate change on animal distribution and range shifts.
• The role of genetics in understanding animal behavior and cognition.
• Exploring the effects of climate change on the biodiversity of animal populations.
• Investigating the role of animal behavior in shaping mating systems and reproductive success.
• The impact of pollution on the behavior and survival of terrestrial animals.
• Exploring the role of animal behavior in shaping the dynamics of animal communities.

This comprehensive list of 300 science thesis topics offers students a diverse range of research opportunities across various scientific disciplines. Whether you are interested in applied mathematics, biology, chemistry, or environmental science, these topics address key challenges, emerging trends, and the future direction of scientific research. By selecting a topic from this list, students can contribute to groundbreaking research that shapes the future of science and technology, advancing both knowledge and innovation in their respective fields.

The Range of Science Thesis Topics

Science is one of the most dynamic and rapidly evolving fields, offering a wide array of research opportunities that span multiple disciplines. From the vast expanses of the universe to the microscopic world of molecular biology, science enables researchers to explore the unknown, solve critical global issues, and contribute to technological innovations that shape the future. For students pursuing degrees in various scientific fields, choosing a thesis topic is a critical step in shaping their academic and professional careers. The range of science thesis topics available today reflects the diversity of scientific inquiry and offers opportunities for students to engage in research that addresses current issues, follows recent trends, and explores future directions in their chosen field.

Current Issues in Science

In today’s world, science plays a pivotal role in solving many of the pressing global challenges we face, including environmental degradation, public health crises, and energy sustainability. Students in scientific disciplines have the opportunity to address these critical issues through their thesis research, contributing to solutions that can have a profound impact on society.

• Climate Change and Environmental Sustainability One of the most urgent global challenges is climate change, which affects ecosystems, economies, and human livelihoods. Scientific research focused on understanding the causes and consequences of climate change has become a top priority. Topics related to environmental sustainability include exploring the impact of greenhouse gas emissions on climate patterns, investigating the role of renewable energy in reducing carbon footprints, and studying the effects of deforestation on biodiversity. Additionally, students can explore the impact of human activities such as urbanization and industrialization on ecosystems and how policy interventions can mitigate these effects.
• Public Health and Global Pandemics The COVID-19 pandemic highlighted the critical need for scientific research in public health, epidemiology, and virology. Research in this area spans understanding the transmission of infectious diseases, developing vaccines, and investigating the long-term effects of viral outbreaks on human health. Thesis topics could focus on epidemiological modeling, the role of public health infrastructure in pandemic preparedness, or the genetic factors that contribute to disease resistance. Additionally, students can explore the social and economic impacts of public health crises and the role of governments and international organizations in responding to pandemics.
• Energy Crisis and Sustainable Development As global energy demand increases, there is a pressing need to transition from fossil fuels to renewable energy sources. Scientific research in this area is focused on developing efficient energy storage solutions, improving solar and wind energy technologies, and exploring the potential of biofuels and nuclear fusion as alternative energy sources. Thesis topics could explore the role of nanotechnology in enhancing solar cell efficiency, the impact of renewable energy adoption on economic growth, or the challenges of implementing large-scale renewable energy projects in developing countries.
• Conservation of Biodiversity The rapid loss of biodiversity is another critical issue facing the planet. Human activities such as habitat destruction, overfishing, and pollution have led to the extinction of species and the degradation of ecosystems. Thesis topics in this area could explore the role of conservation biology in protecting endangered species, the impact of climate change on species migration patterns, or the effectiveness of protected areas and wildlife reserves in conserving biodiversity. Additionally, students can investigate the role of genetics in understanding species adaptation to changing environments.
• Pollution and Environmental Health Pollution, including air, water, and soil contamination, poses serious risks to both human health and the environment. Scientific research aimed at understanding the sources and consequences of pollution is essential for developing effective mitigation strategies. Thesis topics could focus on the effects of microplastics on marine life, the role of industrial pollutants in water contamination, or the development of sustainable waste management practices. Additionally, students could explore the health impacts of air pollution in urban areas or the effectiveness of environmental policies aimed at reducing pollution levels.

Recent Trends in Science

The rapid advancement of technology and scientific understanding has given rise to new trends in scientific research, many of which are interdisciplinary in nature. Recent trends in science reflect the growing importance of collaboration between different scientific fields and the integration of cutting-edge technologies in research.

• Artificial Intelligence and Machine Learning in Scientific Research Artificial intelligence (AI) and machine learning (ML) are transforming the way scientific research is conducted. These technologies are being used in fields such as biology, physics, and chemistry to analyze large datasets, predict outcomes, and automate complex processes. In biology, for instance, AI is being used to analyze genomic data, predict protein structures, and develop new drug therapies. In physics, ML algorithms are being used to model complex systems and simulate the behavior of particles in quantum mechanics. Thesis topics could explore the application of AI in personalized medicine, the role of machine learning in climate modeling, or the ethical implications of using AI in scientific research.
• CRISPR and Genetic Engineering The development of CRISPR-Cas9 technology has revolutionized genetic engineering by providing a precise and efficient method for editing genes. This breakthrough has opened new avenues for research in genetics, biotechnology, and medicine. Thesis topics could focus on the potential applications of CRISPR in treating genetic disorders, the ethical considerations surrounding gene editing in humans, or the use of CRISPR to create genetically modified organisms for agriculture. Additionally, students could explore the role of CRISPR in studying evolutionary processes or its potential use in combating antibiotic resistance.
• Quantum Computing and Its Applications Quantum computing is emerging as a powerful tool in fields such as cryptography, chemistry, and materials science. Unlike classical computers, quantum computers use quantum bits (qubits) to perform calculations at an exponentially faster rate, making them ideal for solving complex problems that are currently beyond the reach of traditional computers. Thesis topics could explore the principles of quantum computing, its potential applications in developing new materials, or its role in advancing cryptography. Additionally, students could investigate the challenges of scaling quantum computers for practical use or the potential impact of quantum computing on industries such as finance and healthcare.
• Nanotechnology and Its Impact on Materials Science Nanotechnology involves the manipulation of matter at the atomic or molecular scale and has wide-ranging applications in fields such as medicine, energy, and electronics. In materials science, nanotechnology is being used to create stronger, lighter, and more durable materials with enhanced properties. Thesis topics could focus on the role of nanotechnology in developing energy-efficient materials, the use of nanoparticles in drug delivery systems, or the environmental implications of nanomaterials. Additionally, students could explore the potential of nanotechnology in creating sustainable solutions for water purification or renewable energy storage.
• Synthetic Biology and Biotechnology Synthetic biology combines biology and engineering to design and construct new biological parts, devices, and systems. This field is playing a critical role in advancing biotechnology, with applications ranging from the production of biofuels to the development of new medical therapies. Thesis topics could explore the use of synthetic biology in creating bio-based materials, the role of biotechnology in addressing food security challenges, or the ethical considerations of creating artificial life forms. Additionally, students could investigate the potential of synthetic biology to revolutionize the production of pharmaceuticals or the role of bioengineering in developing sustainable agricultural practices.

Future Directions in Science

As science continues to evolve, new frontiers of research are emerging, offering exciting opportunities for students to engage in groundbreaking work. These future directions in science are often interdisciplinary and involve the integration of advanced technologies and methodologies.

• Space Exploration and Astrobiology The exploration of space has always been a frontier for scientific discovery, but recent advancements in technology have accelerated research in this area. With missions to Mars, the search for habitable exoplanets, and the potential for human colonization of other planets, space exploration presents numerous opportunities for scientific research. Thesis topics could focus on the challenges of long-term space travel, the potential for life on other planets, or the development of technologies for sustainable living in space. Additionally, students could explore the role of astrobiology in understanding the origins of life on Earth and the potential for life elsewhere in the universe.
• Environmental Genomics and Ecosystem Monitoring Advances in genomics are enabling scientists to study the genetic makeup of entire ecosystems, providing insights into biodiversity, species interactions, and environmental changes. Environmental genomics, also known as metagenomics, involves the analysis of genetic material recovered directly from environmental samples. Thesis topics could explore the use of metagenomics in monitoring ecosystem health, the role of environmental DNA (eDNA) in detecting species presence, or the potential of genomics to inform conservation efforts. Additionally, students could investigate the impact of environmental stressors such as pollution and climate change on genetic diversity within ecosystems.
• Fusion Energy and the Future of Power Generation Fusion energy has long been considered the “holy grail” of sustainable energy production due to its potential to provide limitless, clean energy. While still in the experimental stage, significant progress has been made in fusion research, particularly with projects such as ITER (International Thermonuclear Experimental Reactor). Thesis topics could focus on the scientific principles behind nuclear fusion, the technological challenges of building fusion reactors, or the potential environmental and economic impacts of fusion energy. Additionally, students could explore the role of fusion energy in transitioning to a carbon-neutral future and its potential to address global energy demands.
• Neuroscience and Brain-Machine Interfaces Advances in neuroscience are providing new insights into the functioning of the brain and the potential for brain-machine interfaces (BMIs) to enhance human capabilities. BMIs involve the direct communication between the brain and external devices, enabling applications such as prosthetics, brain-controlled computers, and even the potential for neural enhancement. Thesis topics could explore the role of BMIs in restoring mobility to individuals with spinal cord injuries, the ethical considerations of neural augmentation, or the potential of BMIs to revolutionize the field of neuroprosthetics. Additionally, students could investigate the challenges of developing BMIs for widespread use and the potential societal implications of neural enhancement.
• Synthetic Food Production and Food Security As the global population grows and the demand for food increases, synthetic food production offers a potential solution to food security challenges. Technologies such as lab-grown meat, plant-based alternatives, and precision fermentation are transforming the food industry. Thesis topics could explore the scientific principles behind synthetic food production, the environmental benefits of alternative proteins, or the potential impact of lab-grown meat on traditional agriculture. Additionally, students could investigate the role of synthetic food in addressing global hunger and the challenges of scaling these technologies for mass production.

The range of science thesis topics is as vast and diverse as the field of science itself. Whether addressing current issues such as climate change and public health, exploring recent trends in artificial intelligence and biotechnology, or delving into the future directions of space exploration and fusion energy, students have the opportunity to engage in research that pushes the boundaries of knowledge and contributes to solving some of the world’s most pressing problems. By selecting a thesis topic that aligns with their interests and passions, students can make meaningful contributions to the scientific community and help shape the future of science and technology.

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High-resolution mapping of centromeric proteins using long-read nanopore sequencing , plasticity of ageing in burying beetles , exploring strategies to address trypanocide resistance: lessons from uganda , investigating the roles of classic and unusual rna-binding proteins in staphylococcus aureus survival in hostile environments , exploring the role of three deubiquitinases – uch54, uchl3 and usp7 – in the biology of the malaria parasite , protein crystallisation using low-cost electric-field assisted setups for microbatch, vapour diffusion, and in situ diffraction studies , mechanisms regulating human platelet cytoskeleton dynamics and shape change , investigating mechanisms of synaptic loss in progressive supranuclear palsy , post-transcriptional roles of helix-turn-helix transcription factors in regulation of gene expression in methicillin-resistant staphylococcus aureus , development of a biocompatible lossen rearrangement in escherichia coli , spatial regulation of spindle-associated proteins in oocytes , approximation methods for stochastic systems biology , exploring the role of s-nitrosylation regulators hvgsnor and hvtrxh2 in the barley immune response to blumeria graminis f. sp. hordei , watch-breaker: establishment of a microwell array-based miniaturized thymic organoid model suitable for high throughput applications , bacterial removal of co, ni and mn metals from li-ion battery leachates , modern invasions within the western palearctic: cynipid gallwasps as study models for the development of parasitoid communities , using phylodynamics to inform and evaluate hiv public health interventions across three distinct epidemics , post-transcriptional regulation of fungal cell walls by rna-binding proteins and untranslated regions , evolution of recombination rate variation in a natural population of house sparrows , identification of mutants that affect mono-orientation in meiosis through a mutagenesis screen .

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Senior thesis examples.

Graduating seniors in Biological Sciences have the option of submitting a senior thesis for consideration for Honors and Research Prizes .  Below are some examples of particularly outstanding theses from recent years (pdf):

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Biology Masters Theses Collection

This collection contains open access and campus access Masters theses, made possible through Graduate Studies at the University of Massachusetts Boston. The full content of open access theses is available to all, although some files may have embargoes placed on them and will be made available as soon as possible. The full content of campus access theses is only available to those either on the UMass Boston campus or with a UMass Boston campus username and password. Click on the "Off-Campus UMass Boston Users" link on the record page to download Campus Access publications. Those not on campus and those without a UMass Boston campus username and password may gain access to this thesis through resources like Proquest Dissertations & Theses Global or through Interlibrary Loan.

Theses from 2024 2024

Interplay of Common Climate Change Stressors: Experimental Effects of Diet C:N Ratio and Temperature on Color and Heat Absorption of Tobacco Hornworms , Tyler Barr

The Role of Regulatory RNAs in the Progression and Development of Prostate Fibrosis , Delaney Rose Bowen

Mapping QTL Modulating Rhizosphere Bacterial Communities of Arabidopsis Thaliana , Stuart Morey

The Study of DMRT1 in Zebrafish and How it Impacts Sex Determination , Raymond Michael Poirier

The Effects of Mitochondrial Fission Inhibition on Mitochondrial Quality and Muscle Function in D2-MDX Mouse Model of Duchenne Muscular Dystropy , Hannah Grace Rosen

The Effects of IL-4/IL-13 on Fibrotic Persistance in Primary Human Prostate Fibroblasts , Marissa Sarna-McCarthy

Characterization of the Capicua Interactome , Nathan Michael Strozewski

Theses from 2023 2023

The Arabidopsis thaliana Kinesin Centromere-Associated Protein-E (CENP-E) Is Necessary for Proper Cell Division and Differentiation , Denise Butler

Crisper Locus Combination Affects the Ecology of Enterococcus Faecalis , Kevin Barry Mulkerrins

Theses from 2022 2022

Exploring the Role of Predation on Color and Splotch Patterning of Sphingid Caterpillars Using Artificial Prey , Julia M. Barrone

Identification of Novel Regulators of the Hippo Tumor Suppressor Pathway in the Drosophila Eyeidentification of Novel Regulators of the Hippo Tumor Suppressor Pathway in the Drosophila Eye , Mhamed Bashir

Exploring Urban Effects on Red-Winged Blackbirds (Agelaius Phoeniceus) , Mickayla M. Johnston

Fool Me Once: Characterizing the Response of Notophthalmus Viridescens to Multiple Exposures of Batrachochytrium Salamandrivorans , Julia A. McCartney

Mechanisms of Pathogen Resistance: Understanding Host Associated Defenses of Lithobates Pipiens Against the Amphibian Chytrid Fungi , Aura Yamila Muñiz Torres

A Bacterial Reporter to Detect the Presence of Vibrio Parahaemolyticus in Oyster Hemolymph , Sara W. Quinn

The Effects of Aging on Wound Healing and Limb Regeneration in the Axolotl , Hande Sahin

Polymorphism & Parasites: Structure, Diversity and Selection of the MHCII Genes in a Weakly Electric Fish, Brachyhypopomus Occidentalis , Bruna L. Silva

Small-Scale Salt Marsh Sedimentation in Determined by Interactions Between Cordgrass Morphology and Local Abiotic Factors , Wendi K. White

Theses from 2021 2021

A Comparison of Phagocytosis in Three Caribbean Sea Urchins: Investigating the Role of Compromised Immunity in a Marine Invertebrate Mass Mortality , John P. DeFilippo

In Vivo Analysis of Drosophila Cell Signaling Using Bimolecular Fluorescence Complementation (BiFC) , Claire S. Jackan

Open Wave Height Logger: An Open-Source Pressure Sensor Data Logger for Wave Measurement , Theodore P. Lyman

The Characterization of Antimicrobial Activity from Ctenophores and Cnidaria , Suzanne S. Rossov

Theses from 2019 2019

Daltonien is a Novel Gene that Regulates the Hippo Tumor Suppressor Pathway in the Drosophila Eye , Jessica A. Gosselin

The Tailor RNA-Seq Comparative Analysis Pipeline: A De Novo Disease Biomarker Discovery Workflow that Facilitates High Performance Computing Cluster Use , Andrew S. Judell

Evaluating Differential Gene Expression Using RNA-Sequencing: A Case Study in Diet-Induced Mouse Model Associated with Non-Alcoholic Fatty Liver Disease (NAFLD) and CXCL12-Vs- TGFβ Induced Fibroblast to Myofibroblast Phenoconversion , Arpa Samadder

Theses from 2018 2018

From Symbionts to Pathogens: Interactions within the Amphibian Skin Mucosome , Kelly L. Barnhart

Theses from 2017 2017

Signaling Mechanisms Underlying Cxcl5-Mediated Fibroblast to Myofibroblast Phenoconversion , Timothy K. Belford

Using Hidden Markov Models to Capture Unique Binding Characteristics of Gcn4 and p53 , Cory Colaneri

Student Behavior in a Flipped Introductory Undergraduate Biology Course: Online Interaction Patterns and Self-Regulated Learning Strategies , Casey J. McCabe

Characterization of the Gill and Digestive System Eukaryotic Microbiome (Eukaryome) in the Eastern Oyster, Crassostrea Virginica , Matthew A. Sederberg

The Functions of the Type IV P-Type ATPases DRS2 and Phosphatidylserine in Saccharomyces Cerevisiae Membrane Development , Dang V. Truong

Theses from 2016 2016

The Relationship between SMK1, a Non-Canonical Map Kinase, and GIP1, a Meosis Specific Regulatory Subunit of a PP1-Phosphatase in Saccharomyces Cerevisiae , Stephanie E.J. Cronin

Contextualizing Local Biodiversity Change in the Face of Human Impacts , Jillian C. Dunic

Identification of Regulatory Mechanisms that Contribute to Novel Cell Cycle Outcomes During Host-Microbe Symbiosis , Charles T.S. Puerner

Historical Allopatry and Secondary Contact or Primary Intergradation in the Puerto Rican Crested Anole, Anolis Cristatellus, on Vieques Island , Quynh N. Quach

Genetic Regulation of Germ Cell Development , Emily C. Taylor

Theses from 2015 2015

Evaluating Student Performance and Perceptions in a Flipped Introductory Undergraduate Biology Classroom , Kiley C. Brown

The Role of YBR063c in the MAP Kinase Sporulation Pathway , Alyssa Funk

Function of the Ankyrin3 Bipolar Disorder Risk Gene in Brain and Behavior , Klaudio Gjeluci

Respiratory Behavior in Manduca Sexta Pupae , Yue See Lee

Regulation of Epithelial Morphogenesis by β-Arrestin Kurtz , Katarzyna Maria Piotrowska

Taxonomy of the Bitentaculate Cirratulidae (Polychaeta) , Stacy A. Tewari

Theses from 2014 2014

N-β-Alanyldopamine Metabolism in Sarcophaga Bullata , Hanine Barek

Efficacy of Citizen Science in Water Quality Studies: A Macroinvertebrate Biomonitoring Project in the Charles River Watershed, Massachusetts , Christina E. Ciarfella

Students' Attitudes towards Science and Science Learning In an Introductory Undergraduate Biology Course , Nicole Floro

Transcriptional Regulation of Sinorhizobium Meliloti Cell Cycle-Related Genes in the Δcbra Mutant and Root Nodules of Medicago Sativa , Corey S. Hazekamp

Identification of NF-kB-like Transcription Factor In Arabidopsis Thaliana , Neermala Poudel Neupane

Skeletal and Tissue Response to Automated, Continuous, Curvilinear Distraction Osteogenesis: A Clinical and Histological Study , Brad John Scott Tricomi

Theses from 2013 2013

The Occurrence and Distribution of Enterococcus in an Urban Coastal Watershed , Steven Bryant-Allen

Comparative Genomics of the Spergen 1 Gene and Expression of Recombinant Mouse Y-Box Protein 3 , Jennifer D. Curtis

Anti-Apoptotic Role of β-Arrestin Kurtz in Drosophila Development , Niusha Nikkholgh

The Role of the Histidine Kinase, CbrA, in Sinorhizobium Meliloti Cell Cycle Regulation and Symbiotic Development , Craig Shaw Sadowski

Identifying In Situ Conservation Priorities for Teosinte , Crystal A. Sorgini

In Vivo Analysis of Drosophila Beta-Arrestin Kurtz and Notch Signaling Complexes , Wenjian Xu

Theses from 2012 2012

Investigating the Role of an Understudied North Atlantic Right Whale Habitat: Right Whale Movement, Ecology, and Distribution in Jeffreys Ledge , Kathryn Longley

Species Richness, Distribution and Relative Abundance of Freshwater Mussels (Unionidae) of the Strawberry River, Arkansas , Sujata Poudel

Theses from 2011 2011

Investigating Notch and Kurtz Interaction Networks , Sukanya Basu

Bladder Cancer Genomics: Mutations, Deletions, and Amplifications , Yvonne Chekaluk

Ecological Stoichiometry and Consumer-Driven Nutrient Recycling of Elliptio complanata (Lightfoot 1786) in a Northeastern Coastal Zone Pond , Nicole Marie Fallon

Biodiversity in an Isolated Suburban Reservation: Amphibians in the Middlesex Fells , Matthew William Gage

Comparative Sequence Analysis of Fatty Acid Desaturase 2 (FAD2) cDNA Sequences from the Compositae [Asteraceae] , Paul Ames Muller Jr.

A Long-Term Control Project for an Invasive Plant: Assessment of Phragmites Australis Reduction and Redevelopment of Native Vegetation in Interdunal Swales of Sandy Neck Barrier Beach, Cape Cod, Massachusetts , Dena Tomassi

Identification of TIR-Domain Containing Genes and Proteins in the Moon (Aurelia Aurita) and Comb Jellyfish (Mnemiopsis Leidyi) , Christine M. Turcotte

Exploring Alternative Methods to Improve the Detection of Apoptosis in a Solution-Based Assay , Kim Har Wong

Vancomycin-Resistant Bacteria in Recreational Beach Sands , Yang Yang

Theses from 2010 2010

SPO71 is Required for Proper Prospore Membrane Size in Saccharomyces Cerevisiae , Crystal Baker

Reproductive Status and Body Condition of Atlantic Bluefin Tuna, Thunnus thynnus, in the Gulf of Maine , Jennifer Lane Goldstein

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The School promotes an interdisciplinary approach to both applied and fundamental research problems and to postgraduate training. Research in the School is organised into three major interdisciplinary centres: the Scottish Oceans Institute (SOI), Biomedical Sciences Research Complex (BSRC) and Centre for Biological Diversity (CBD). Together these centres encompass the full spectrum of research in biological sciences, spanning investigations on the properties and behaviour of individual molecules to planetary environmental dynamics.

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Social plasticity within and across generations : testing the role of plasticity in rapid evolution in field cricket teleogryllus oceanicus , rhythmically repeated patterns of pulsed vocalizations in wild narwhals (monodon monoceros) , factors influencing growth and spore germination of species of boletus , density estimation and time trend analysis of large herbivores in nagarhole, india , designing a shipboard line transect survey to estimate cetacean abundance off the azores archipelago, portugal .